WIN 55,212-2 Mesylate | B3012

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkyl indole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. It shows antihyperalgesic and anti-inflammatory properties. It (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve in primary cultures of rat cerebral cortex neurons. It also evokes CGRP release from trigeminal ganglion neurons in vitro (EC₅₀=26 μM) in a concentration- and calcium-dependent manner.

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkyl indole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. It shows antihyperalgesic and anti-inflammatory properties. It (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve in primary cultures of rat cerebral cortex neurons. It also evokes CGRP release from trigeminal ganglion neurons in vitro (EC₅₀=26 μM) in a concentration- and calcium-dependent manner.

B3012 | WIN 55,212-2 Mesylate DataSheet

Alternate Name/Synonyms: (R)-(+)-WIN 55,212-2 mesylate; (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)methanone methanesulfonate; methanesulfonic acid; [(11R)-2-methyl-11-(morpholin-4-ylmethyl)-9-oxa-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraen-3-yl]-naphthalen-1-ylmethanone; (R)-5-Methyl-3-(morpholinomethyl)-6-(1-naphthylcarbonyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indole Methanesulfonate; [(3R)-2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone, monomethanesulfonate

Appearance: White to off-white Powder

Formulation:

CAS Number: 131543-23-2

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₂₈H₃₀N₂O₆S

Molecular Weight: 522.6

Cell-Permeable?: TRUE

Purity: >98%

Solubilities: ~30 mg/ml in DMSO and DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A Cannabinoid Receptor (CB1 and CB2) Agonist

MDL Number: MFCD00153882

PubChem CID: 6604176

SMILES: CC1=C(C2=C3N1C(COC3=CC=C2)CN4CCOCC4)C(=O)C5=CC=CC6=CC=CC=C65.CS(=O)(=O)O

InChi: InChI=1S/C27H26N2O3.CH4O3S/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28;1-5(2,3)4/h2-11,20H,12-17H2,1H3;1H3,(H,2,3,4)/t20-;/m1./s1

InChi Key: FSGCSTPOPBJYSX-VEIFNGETSA-N