Description
WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM (induced R7T1 proliferation). More recently, WS3 has been found to mediate proliferation of primary retinal pigment epithelial cells. After WS3 removal, the retinal cells differentiated into a functional monolayer and remained functional in vivo, preserving vision when they were transplanted into RCS rats used as a model of retinal degeneration.
WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM (induced R7T1 proliferation). More recently, WS3 has been found to mediate proliferation of primary retinal pigment epithelial cells.
Alternate Name/Synonyms: N-[6-[4-[[[[4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide, WS-3
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1421227-52-2
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₈H₃₀F₃N₇O₃
Molecular Weight: 569.58
Cell-Permeable?: Y
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A cell proliferation inducer
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C(C1CC1)NC2=NC=NC(OC3=CC=C(NC(NC4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4)=O)C=C3)=C2
InChi: InChI=1S/C28H30F3N7O3/c1-37-10-12-38(13-11-37)16-19-4-5-21(14-23(19)28(29,30)31)35-27(40)34-20-6-8-22(9-7-20)41-25-15-24(32-17-33-25)36-26(39)18-2-3-18/h4-9,14-15,17-18H,2-3,10-13,16H2,1H3,(H2,34,35,40)(H,32,33,36,39)
InChi Key: KIKOYRNAERIVSJ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |