Description
WZ-3146 is a mutant selective EGFR inhibitor with IC₅₀s of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750, EGFRE746_A750/T790M and EGFR, respectively.
WZ-3146 is a mutant selective EGFR inhibitor with IC₅₀s of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750, EGFRE746_A750/T790M and EGFR, respectively.
Alternate Name/Synonyms: N-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1214265-56-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₅ClN₆O₂
Molecular Weight: 464.95
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A mutant selective EGFR inhibitor
MDL Number: N/A
PubChem CID: 44607360
SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl
InChi: InChI=1S/C24H25ClN6O2/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-2
InChi Key: APHGZZPEOCCYNO-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |