XEN445 | 2681

XEN445 is a potent and selective endothelial lipase (EL) inhibitor. It displays good ADME and PK properties and shows in vivo efficacy in raising plasma HDL cholesterol concentration in mice.

XEN445 is a potent and selective endothelial lipase (EL) inhibitor. It displays good ADME and PK properties and shows in vivo efficacy in raising plasma HDL cholesterol concentration in mice.

2681 | XEN445 DataSheet

Alternate Name/Synonyms: (S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1515856-92-4

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₇F₃N₂O₃

Molecular Weight: 366.33

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective endothelial lipase (EL) inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(O)C1=CC(C(F)(F)F)=CC=C1N2C[C@@H](OCC3=NC=CC=C3)CC2

InChi: InChI=1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1

InChi Key: NBGRERFNOKZQLO-AWEZNQCLSA-N