Xestospongin C | 2621

Xestospongin C is a marine natural product isolated from Pacific basin sponges; it antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Xestospongin C blocks the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 µM. Xe C also inhibits the sarcoplasmic reticulum Ca²⁺- ATPase pump at concentrations of 700 nM.

Xestospongin C is a marine natural product isolated from Pacific basin sponges; it antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Xestospongin C blocks the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 µM. Xe C also inhibits the sarcoplasmic reticulum Ca²⁺- ATPase pump at concentrations of 700 nM.

2621 | Xestospongin C DataSheet

Alternate Name/Synonyms: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine; XeC; Araguspongine E

Appearance: A clear film

Formulation: N/A

CAS Number: 88903-69-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₅₀N₂O₂

Molecular Weight: 446.71

Cell-Permeable?: Yes

Purity: >90%

Solubilities: DMSO (~ 2 mM) or EtOH (~ 2 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An inhibitor of IP3-mediated Ca²⁺ release

MDL Number: MFCD01862629

PubChem CID: 9846431

SMILES: C1CCCC2CCN3CCCC(C3O2)CCCCCCC4CCN5CCCC(C5O4)CC1

InChi: InChI=1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1

InChi Key: PQYOPBRFUUEHRC-HCKQMYSWSA-N