XL-147 | 9401

XL-147 is an ATP-competitive, highly selective, and reversible pan-class I phosphoinositide 3-kinase (PI3K) inhibitor. It inhibits PI3K p110α, -β, -γ, and -δ isoforms, with IC₅₀ values of 48, 617, 10, and 260 nmol/L, respectively, measured in biochemical assays. XL-147 displays antitumor activity.

XL-147 is an ATP-competitive, highly selective, and reversible pan-class I phosphoinositide 3-kinase (PI3K) inhibitor. It inhibits PI3K p110α, -β, -γ, and -δ isoforms, with IC₅₀ values of 48, 617, 10, and 260 nmol/L, respectively, measured in biochemical assays. XL-147 displays antitumor activity.

9401 | XL-147 DataSheet

Alternate Name/Synonyms: N-[3-(2,1,3-benzothiadiazol-5-ylamino)quinoxalin-2-yl]-4-methylbenzenesulfonamide; SAR245408; Pilaralisib

Appearance: Off-white solid

Formulation: N/A

CAS Number: 956958-53-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₆N₆O₂S₂

Molecular Weight: 448.52

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 3 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A phosphoinositide 3-kinase (PI3K) inhibitor

MDL Number: N/A

PubChem CID: 56599306

SMILES: CC(C)(C(=O)NC1=CC(=CC=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=C(C=CC(=C4)OC)Cl)N

InChi: InChI=1S/C25H25ClN6O4S/c1-25(2,27)24(33)28-15-7-6-8-17(13-15)37(34,35)32-23-22(29-19-9-4-5-10-20(19)30-23)31-21-14-16(36-3)11-12-18(21)26/h4-14H,27H2,1-3H3,(H,28,33)(H,29,31)(H,30,32)

InChi Key: QINPEPAQOBZPOF-UHFFFAOYSA-N