Description
XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC₅₀ = 2.2 nM). Inhibits JAK1 (IC₅₀ = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC₅₀ = 348.3 nM) at higher concentrations. XL019 displays significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model.
XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC₅₀ = 2.2 nM). Inhibits JAK1 (IC₅₀ = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC₅₀ = 348.3 nM) at higher concentrations. XL019 displays significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model.
Alternate Name/Synonyms: (S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide
Appearance: Light yellow to light brown solid
Formulation: N/A
CAS Number: 945755-56-6
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₈N₆O₂
Molecular Weight: 444.53
Cell-Permeable?: Yes
Purity: >98% by HPLC
Solubilities: DMSO (~ 15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent JAK2 inhibitor
MDL Number: N/A
PubChem CID: 57990869
SMILES: C1CC(NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5
InChi: InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m0/s1
InChi Key: ISOCDPQFIXDIMS-QHCPKHFHSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |