XL019 | 2609

XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC₅₀ = 2.2 nM). Inhibits JAK1 (IC₅₀ = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC₅₀ = 348.3 nM) at higher concentrations. XL019 displays significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model.

XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC₅₀ = 2.2 nM). Inhibits JAK1 (IC₅₀ = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC₅₀ = 348.3 nM) at higher concentrations. XL019 displays significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model.

2609 | XL019 DataSheet

Alternate Name/Synonyms: (S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide

Appearance: Light yellow to light brown solid

Formulation: N/A

CAS Number: 945755-56-6

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₈N₆O₂

Molecular Weight: 444.53

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO (~ 15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent JAK2 inhibitor

MDL Number: N/A

PubChem CID: 57990869

SMILES: C1CC(NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5

InChi: InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m0/s1

InChi Key: ISOCDPQFIXDIMS-QHCPKHFHSA-N