XL765 | 2551

XL765 is a dual inhibitor of mTOR/PI3K with potential anticancer activities. XL765 inhibits both PI3 kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cell populations. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy.

XL765 is a dual inhibitor of mTOR/PI3K with potential anticancer activities. XL765 inhibits both PI3 kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cell populations. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy.

2551 | XL765 DataSheet

Alternate Name/Synonyms: 2-Amino-8-ethyl-4-methyl-6-(lH-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one; SAR245409

Appearance: White solid

Formulation: N/A

CAS Number: 934493-76-2

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₄N₆O

Molecular Weight: 270.29

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A dual PI3K/mTOR inhibitor

MDL Number: N/A

PubChem CID: 16123056

SMILES: CCN1C2=NC(=NC(=C2C=C(C1=O)C3=CC=NN3)C)N

InChi: InChI=1S/C13H14N6O/c1-3-19-11-8(7(2)16-13(14)17-11)6-9(12(19)20)10-4-5-15-18-10/h4-6H,3H2,1-2H3,(H,15,18)(H2,14,16,17)

InChi Key: RGHYDLZMTYDBDT-UHFFFAOYSA-N