XRK3F2 | B2381

XRK3F2 is an inhibitor of the p62-ZZ domain (Sequestosome 1) that inhibits MM cell growth and BMSC growth enhancement of human MM cells. XRK3F2 induces dramatic cortical bone formation that is restricted to MM containing bones and blocks the effects and upregulation of tumor necrosis factor alpha (TNFα), an osteoblast (OB) differentiation inhibitor that is increased in the MM bone marrow microenvironment and utilizes signaling complexes formed on p62-ZZ, in BMSC.

XRK3F2 is an inhibitor of the p62-ZZ domain (Sequestosome 1) that inhibits MM cell growth and BMSC growth enhancement of human MM cells. XRK3F2 induces dramatic cortical bone formation that is restricted to MM containing bones and blocks the effects and upregulation of tumor necrosis factor alpha (TNFα), an osteoblast (OB) differentiation inhibitor that is increased in the MM bone marrow microenvironment and utilizes signaling complexes formed on p62-ZZ, in BMSC.

B2381 | XRK3F2 DataSheet

Alternate Name/Synonyms: 2-((3,4-bis((4-fluorobenzyl)oxy)benzyl)amino)ethan-1-ol hydrochloride

Appearance: Crystalline solid

Formulation:

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₃H₂₄ClF₂NO₃

Molecular Weight: 435.9

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >5 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor

MDL Number:

PubChem CID: 135000000

SMILES: C1=CC(=CC=C1COC2=C(C=C(C=C2)CNCCO)OCC3=CC=C(C=C3)F)F.Cl

InChi: InChI=1S/C23H23F2NO3.ClH/c24-20-6-1-17(2-7-20)15-28-22-10-5-19(14-26-11-12-27)13-23(22)29-16-18-3-8-21(25)9-4-18;/h1-10,13,26-27H,11-12,14-16H2;1H

InChi Key: OKFZPRHMUQRCLJ-UHFFFAOYSA-N