Description
XRK3F2 is an inhibitor of the p62-ZZ domain (Sequestosome 1) that inhibits MM cell growth and BMSC growth enhancement of human MM cells. XRK3F2 induces dramatic cortical bone formation that is restricted to MM containing bones and blocks the effects and upregulation of tumor necrosis factor alpha (TNFα), an osteoblast (OB) differentiation inhibitor that is increased in the MM bone marrow microenvironment and utilizes signaling complexes formed on p62-ZZ, in BMSC.
XRK3F2 is an inhibitor of the p62-ZZ domain (Sequestosome 1) that inhibits MM cell growth and BMSC growth enhancement of human MM cells. XRK3F2 induces dramatic cortical bone formation that is restricted to MM containing bones and blocks the effects and upregulation of tumor necrosis factor alpha (TNFα), an osteoblast (OB) differentiation inhibitor that is increased in the MM bone marrow microenvironment and utilizes signaling complexes formed on p62-ZZ, in BMSC.
Alternate Name/Synonyms: 2-((3,4-bis((4-fluorobenzyl)oxy)benzyl)amino)ethan-1-ol hydrochloride
Appearance: Crystalline solid
Formulation:
CAS Number: N/A
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₃H₂₄ClF₂NO₃
Molecular Weight: 435.9
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: >5 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor
MDL Number:
PubChem CID: 135000000
SMILES: C1=CC(=CC=C1COC2=C(C=C(C=C2)CNCCO)OCC3=CC=C(C=C3)F)F.Cl
InChi: InChI=1S/C23H23F2NO3.ClH/c24-20-6-1-17(2-7-20)15-28-22-10-5-19(14-26-11-12-27)13-23(22)29-16-18-3-8-21(25)9-4-18;/h1-10,13,26-27H,11-12,14-16H2;1H
InChi Key: OKFZPRHMUQRCLJ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |