Description
YH239-EE is potent p53-MDM2 interaction inhibitor that induces cell cycle arrest leading to potential apoptosis by p53 activation and downstream target in AML cells with p53 mutation
YH239-EE is potent p53-MDM2 interaction inhibitor that induces cell cycle arrest leading to potential apoptosis by p53 activation and downstream target in AML cells with p53 mutation
Alternate Name/Synonyms: 6-Chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid Ethyl Ester
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1364488-67-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₇Cl₂N₃O₄
Molecular Weight: 504.41
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO(>50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent p53-MDM2 interaction inhibitor
MDL Number: N/A
PubChem CID: 56943013
SMILES: CCOC(=O)C1=C(C2=C(N1)C=C(C=C2)Cl)C(C(=O)NC(C)(C)C)N(CC3=CC=C(C=C3)Cl)C=O
InChi: InChI=1S/C25H27Cl2N3O4/c1-5-34-24(33)21-20(18-11-10-17(27)12-19(18)28-21)22(23(32)29-25(2,3)4)30(14-31)13-15-6-8-16(26)9-7-15/h6-12,14,22,28H,5,13H2,1-4H3,(H,29,32)
InChi Key: OTUBDDRFPQLPKD-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |