YH239-EE | B1229

YH239-EE is potent p53-MDM2 interaction inhibitor that induces cell cycle arrest leading to potential apoptosis by p53 activation and downstream target in AML cells with p53 mutation

YH239-EE is potent p53-MDM2 interaction inhibitor that induces cell cycle arrest leading to potential apoptosis by p53 activation and downstream target in AML cells with p53 mutation

B1229 | YH239-EE DataSheet

Alternate Name/Synonyms: 6-Chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid Ethyl Ester

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1364488-67-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₇Cl₂N₃O₄

Molecular Weight: 504.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent p53-MDM2 interaction inhibitor

MDL Number: N/A

PubChem CID: 56943013

SMILES: CCOC(=O)C1=C(C2=C(N1)C=C(C=C2)Cl)C(C(=O)NC(C)(C)C)N(CC3=CC=C(C=C3)Cl)C=O

InChi: InChI=1S/C25H27Cl2N3O4/c1-5-34-24(33)21-20(18-11-10-17(27)12-19(18)28-21)22(23(32)29-25(2,3)4)30(14-31)13-15-6-8-16(26)9-7-15/h6-12,14,22,28H,5,13H2,1-4H3,(H,29,32)

InChi Key: OTUBDDRFPQLPKD-UHFFFAOYSA-N