YKL-05-099 | B3387

YKL-05-099 | B3387

Description: YKL-05-099 is an inhibitor of the salt-inducible kinase (SIK1 and SIK3; IC50s: 10 and 30 nM, respectively). It displays less potency towards SIK2 (IC50 = 40 nM). YKL-05-099 Suppresses acute myeloid leukemia progression in vivo.

Alternate Name/Synonyms: 3-(2-chloro-6-methylphenyl)-7-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]-1-(5-methoxypyridin-2-yl)-4H-pyrimido[4,5-d]pyrimidin-2-one

Appearance: Solid

Formulation:

CAS Number: 1936529-65-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₃₄ClN₇O₃

Molecular Weight: 600.11

Cell-Permeable?: False

Purity: ≥98%

Solubilities: >50 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A saltase (SIK) inhibitor

MDL Number:

PubChem CID: 121596782

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/121596782

SMILES: CC1=C(C(=CC=C1)Cl)N2CC3=CN=C(N=C3N(C2=O)C4=NC=C(C=C4)OC)NC5=C(C=C(C=C5)C6CCN(CC6)C)OC

InChi: InChI=1S/C32H34ClN7O3/c1-20-6-5-7-25(33)29(20)39-19-23-17-35-31(37-30(23)40(32(39)41)28-11-9-24(42-3)18-34-28)36-26-10-8-22(16-27(26)43-4)21-12-14-38(2)15-13-21/h5-11,16-18,21H,12-15,19H2,1-4H3,(H,35,36,37)

InChi Key: VQINULODWGEVBB-UHFFFAOYSA-N

Category: Biochemicals