Yoda-1 | B3335

Yoda -1 is a synthetic small molecule that acts as an agonist for both human and mouse Piezo1. Characterization of Yoda1 in artificial droplet lipid bilayers shows that Yoda1 activates purified Piezo1 channels in the absence of other cellular components. Yoda1 will serve as a key tool to study Piezo1 regulation and function.

Yoda -1 is a synthetic small molecule that acts as an agonist for both human and mouse Piezo1. Characterization of Yoda1 in artificial droplet lipid bilayers shows that Yoda1 activates purified Piezo1 channels in the absence of other cellular components. Yoda1 will serve as a key tool to study Piezo1 regulation and function.

B3335 | Yoda-1 DataSheet

Alternate Name/Synonyms: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine

Appearance: White solid

Formulation:

CAS Number: 448947-81-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₈Cl₂N₄S₂

Molecular Weight: 355.27

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A piezo1 channel activator

MDL Number:

PubChem CID: 2746822

SMILES: ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1

InChi: InChI=1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2

InChi Key: BQNXBSYSQXSXPT-UHFFFAOYSA-N