YU238259 | B2155

YU238259 is a potent inhibitor of Homology-Dependent DNA Repair (HDR). YU238259 displays potent synthetic lethality in the setting of DNA damage response and DNA repair defects. YU238259 specifically inhibits homology-dependent DNA repair, but not non-homologous end-joining, in cell-based GFP reporter assays.

YU238259 is a potent inhibitor of Homology-Dependent DNA Repair (HDR). YU238259 displays potent synthetic lethality in the setting of DNA damage response and DNA repair defects. YU238259 specifically inhibits homology-dependent DNA repair, but not non-homologous end-joining, in cell-based GFP reporter assays.

B2155 | YU238259 DataSheet

Alternate Name/Synonyms: N-(2-(5-chloropyridin-2-yl)ethyl)-4-(((4-methoxyphenyl)sulfonamido)methyl)benzamide

Appearance: White solid

Formulation: N/A

CAS Number: 1943733-16-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₂ClN₃O₄S

Molecular Weight: 459.94

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent Homology-Dependent DNA Repair (HDR) inhibitor

MDL Number: N/A

PubChem CID: 121473004

SMILES: COC1=CC=C(C=C1)S(=O)(=O)NCC2=CC=C(C=C2)C(=O)NCCC3=NC=C(C=C3)Cl

InChi: InChI=1S/C22H22ClN3O4S/c1-30-20-8-10-21(11-9-20)31(28,29)26-14-16-2-4-17(5-3-16)22(27)24-13-12-19-7-6-18(23)15-25-19/h2-11,15,26H,12-14H2,1H3,(H,24,27)

InChi Key: BIHURSOREGLQBB-UHFFFAOYSA-N