Description
Zalcitabine is an antiviral pyrimidine nucleoside analog effective against HIV replication. In cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV reverse transcriptase (Ki = 51 nM). It incorporates into viral DNA where it terminates chain elongation when the missing hydroxyl group is encountered
Zalcitabine is an antiviral pyrimidine nucleoside analog effective against HIV replication. In cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV reverse transcriptase (Ki = 51 nM). It incorporates into viral DNA where it terminates chain elongation when the missing hydroxyl group is encountered.
Alternate Name/Synonyms: 2′,3′-Dideoxycytidine,ddC,Hivid,NSC-606170,Ro 24-2027/000
Appearance: White to off-white solid
Formulation:
CAS Number: 7481-89-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₉H₁₃N₃O₃
Molecular Weight: 211.22
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~0.2 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An antiviral agent
MDL Number: MFCD00012188
PubChem CID: 24066
SMILES: C1CC(OC1CO)N2C=CC(=NC2=O)N
InChi: InChI=1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1
InChi Key: WREGKURFCTUGRC-POYBYMJQSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |