ZK-756326 dihydrochloride | B3390

ZK-756326 dihydrochloride | B3390

Description: ZK-756326 is a non-peptide agonist of the CC chemokine receptor CCR8. It inhibits binding of CCL1 to human CCR8 (IC50 = 1.8 µM) and induces Gai-mediated calcium-mobilization in U87 cells expressing the receptor. It displays greater than 28-fold selectivity for CCR8 over 26 other GPCRs but also binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2B, 5-HT2C, and 5-HT5A with IC50 values of 5.4, 4.4, 34.8, and 16 µM, respectively.

Alternate Name/Synonyms: 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]-ethanol, dihydrochloride

Appearance: Crystalline solid

Formulation:

CAS Number: 1780259-94-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₈N₂O₃ • 2HCl

Molecular Weight: 429.4

Cell-Permeable?: True

Purity: ≥98%

Solubi/ml Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A non-peptide agonist of the CC chemokine receptor CCR8

MDL Number:

PubChem CID: 56972201

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/56972201

SMILES: OCCOCCN(CC1)CCN1CC2=CC=CC(OC3=CC=CC=C3)=C2.Cl.Cl

InChi: InChI=1S/C21H28N2O3.2ClH/c24-14-16-25-15-13-22-9-11-23(12-10-22)18-19-5-4-8-21(17-19)26-20-6-2-1-3-7-20;;/h1-8,17,24H,9-16,18H2;2*1H

InChi Key: MPACCEKWFGWZHS-UHFFFAOYSA-N

Category: Biochemicals