ZLN024 hydrochloride | B2034

ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC₅₀s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively. Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio.

ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC₅₀s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively. Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio.

B2034 | ZLN024 hydrochloride DataSheet

Alternate Name/Synonyms: 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 723249-01-2 (Free base)

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₃BrN₂OS.HCl

Molecular Weight: 361.69

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An allosteric AMPK activator

MDL Number: N/A

PubChem CID: 91654626

SMILES: CC1=CC(=C(C=C1)OCCSC2=NC=CC=N2)Br.Cl

InChi: InChI=1S/C13H13BrN2OS.ClH/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13;/h2-6,9H,7-8H2,1H3;1H

InChi Key: MMQCYIMDROWWFE-UHFFFAOYSA-N