1,5-Isoquinolinediol | 2415

1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. Also acts as a neuroprotective agent.

1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death.

2415 | 1,5-Isoquinolinediol DataSheet

Alternate Name/Synonyms: 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ; NSC 65585

Appearance: Off-white solid

Formulation: N/A

CAS Number: 5154-02-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₉H₇NO₂

Molecular Weight: 161.16

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (>35 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A poly(ADP-ribose) synthetase (PARP1) inhibitor

MDL Number: MFCD00006900

PubChem CID: 1340

SMILES: C1=CC2=C(C=CNC2=O)C(=C1)O

InChi: InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)

InChi Key: LFUJIPVWTMGYDG-UHFFFAOYSA-N