Antibody Engineering for COVID-19


Antibody engineering for COVID-19 involves the development and optimization of antibodies to target the SARS-CoV-2 virus, which causes COVID-19.

This field focuses on creating antibodies with enhanced efficacy, specificity, and safety profiles for use in diagnostics, therapeutics, and vaccines.

Several approaches are being used in antibody engineering for COVID-19:


-Monoclonal Antibodies (mAbs):

Monoclonal antibodies are designed to target specific epitopes on the SARS-CoV-2 spike protein, blocking viral entry into host cells.

These mAbs can be engineered for increased potency and half-life.

An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer



-Neutralizing Antibodies:

Neutralizing antibodies are a subset of antibodies that can bind to the virus and prevent it from infecting cells.

Engineering approaches are used to enhance the neutralizing activity of these antibodies.

Neutralizing Antibody



Bispecific Antibodies:

Bispecific antibodies are designed to simultaneously target two different epitopes, potentially enhancing their efficacy against SARS-CoV-2 and reducing the likelihood of resistance development.


Bispecific monoclonal antibody



Fusion Proteins:

Fusion proteins combine the binding domains of antibodies with other proteins to create molecules with novel functions, such as targeting specific immune cells or enhancing antiviral activity.

The structures of a series of Fc fusion proteins


Antibody Cocktails:

Combining multiple antibodies targeting different epitopes on the virus can enhance efficacy and reduce the risk of viral escape mutations.


SARS-CoV-2 cocktail with three antibodies potent in preclinical testing


--> Antibody engineering for COVID-19 has led to the development of several promising therapeutics, including monoclonal antibody treatments such as bamlanivimab and etesevimab, as well as vaccines based on viral vector platforms that deliver genes encoding SARS-CoV-2 antibodies.

--> Overall, antibody engineering is a rapidly evolving field that holds great promise for combating COVID-19 and future pandemics.