Freund's Adjuvant

Freund's Adjuvant


Freund's adjuvant is a substance used in immunology and vaccinology to enhance the immune response to an antigen. Freund's adjuvant is particularly useful when preparing vaccines or immunizing animals for antibody production in research settings.

There are two main types of Freund's adjuvant:

  1. Complete Freund's Adjuvant (CFA): FCA is a water-in-oil emulsion that contains killed Mycobacterium tuberculosis or Mycobacterium butyricum bacteria. The presence of these bacteria, along with the mineral oil component, creates a strong immune response by stimulating both the innate and adaptive immune systems. FCA is known for its potent adjuvant properties and is typically used for the initial immunization or priming phase.
  2. Incomplete Freund's Adjuvant (IFA): FIA is similar to FCA but lacks the mycobacterial component. It consists of the mineral oil component alone, without the bacteria. While FIA is less potent than FCA, it still enhances the immune response and is often used for booster immunizations following initial priming with FCA.

Mechanism of action for incomplete Freund's adjuvant (IFA) as a peptide...  | Download Scientific Diagram

The mechanism of action of Freund's adjuvants involves several factors:

  • The mineral oil component serves as a depot, prolonging the release of the antigen and enhancing its retention at the injection site.
  • The mycobacterial components in FCA activate innate immune cells, such as macrophages, leading to the release of pro-inflammatory cytokines and chemokines.
  • This inflammatory environment promotes the recruitment and activation of antigen-presenting cells (e.g., dendritic cells), which efficiently process and present the antigen to T cells.
  • The activation of T cells leads to their proliferation and differentiation into effector cells, including B cells that produce antibodies specific to the antigen.

 

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  • Freund's Incomplete Adjuvant

    Freund's Incomplete Adjuvant | VAdv-Ly0008

    708

    NULL737.00
    Freund's Incomplete Adjuvant | VAdv-Ly0008 | Gentaur UK, US & Europe Distribution Short Description: Freund's Adjuvant, Incomplete, Water-in-oil emulsion Vaccine adjuvant. Status: customized Expected Delivery Time: inquire
    708-VAdv-Ly0008-GEN
    NULL737.00
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  • Freund's Complete Adjuvant (Solution)

    Freund's Complete Adjuvant (Solution) | VAdv-Ly0006

    708

    NULL439.00
    Freund's Complete Adjuvant (Solution) | VAdv-Ly0006 | Gentaur UK, US & Europe Distribution Short Description: Freund's Adjuvant, Complete, Water-in-oil emulsion Vaccine adjuvant. Status: customized Expected Delivery Time: inquire
    708-VAdv-Ly0006-GEN
    NULL439.00
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  • Freund's Complete Adjuvant (Suspension)

    Freund's Complete Adjuvant (Suspension) | VAdv-Ly0004

    708

    NULL393.00
    Freund's Complete Adjuvant (Suspension) | VAdv-Ly0004 | Gentaur UK, US & Europe Distribution Short Description: Freund's Adjuvant, Complete, Water-in-oil emulsion Vaccine adjuvant. Status: customized Expected Delivery Time: inquire
    708-VAdv-Ly0004-GEN
    NULL393.00
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  • Incomplete Freund's Adjuvant

    Incomplete Freund's Adjuvant

    445

    NULL123.00
    Incomplete Freund's Adjuvant - Cat Number: 7002 From . Research Field: In vivo Research Clonality: N/A Cross-Reactivity: Host Origin: N/A Applications: N/A Isotype: N/A Detection Range: N/A Sample Type: N/A Concentration: N/A Immunogen: DESCRIPTION:...
    445-7002-GEN
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  • Complete Freund's Adjuvant, 5 mg/ml

    Complete Freund's Adjuvant, 5 mg/ml

    445

    NULL184.00
    Complete Freund's Adjuvant, 5 mg/ml - Cat Number: 7023 From . Research Field: In vivo Research Clonality: N/A Cross-Reactivity: Host Origin: N/A Applications: N/A Isotype: N/A Detection Range: N/A Sample Type: N/A Concentration: N/A Immunogen: PRODUCT...
    445-7023-GEN
    NULL184.00
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  • Complete Freund's Adjuvant, 4 mg/ml

    Complete Freund's Adjuvant, 4 mg/ml

    445

    NULL161.00
    Complete Freund's Adjuvant, 4 mg/ml - Cat Number: 7001 From . Research Field: In vivo Research Clonality: N/A Cross-Reactivity: Host Origin: N/A Applications: N/A Isotype: N/A Detection Range: N/A Sample Type: N/A Concentration: N/A Immunogen: PRODUCT...
    445-7001-GEN
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  • Complete Freund's Adjuvant, 3 mg/ml

    Complete Freund's Adjuvant, 3 mg/ml

    445

    NULL138.00
    Complete Freund's Adjuvant, 3 mg/ml - Cat Number: 7015 From . Research Field: In vivo Research Clonality: N/A Cross-Reactivity: Host Origin: N/A Applications: N/A Isotype: N/A Detection Range: N/A Sample Type: N/A Concentration: N/A Immunogen: PRODUCT...
    445-7015-GEN
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  • Complete Freund's Adjuvant, 20 mg/ml

    Complete Freund's Adjuvant, 20 mg/ml

    445

    NULL342.00
    Complete Freund's Adjuvant, 20 mg/ml - Cat Number: 7024 From . Research Field: In vivo Research Clonality: N/A Cross-Reactivity: Host Origin: N/A Applications: N/A Isotype: N/A Detection Range: N/A Sample Type: N/A Concentration: N/A Immunogen: PRODUCT...
    445-7024-GEN
    NULL342.00
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  • Complete Freund's Adjuvant, 2 mg/ml

    Complete Freund's Adjuvant, 2 mg/ml

    445

    NULL137.00
    Complete Freund's Adjuvant, 2 mg/ml - Cat Number: 7009 From . Research Field: In vivo Research Clonality: N/A Cross-Reactivity: Host Origin: N/A Applications: N/A Isotype: N/A Detection Range: N/A Sample Type: N/A Concentration: N/A Immunogen: PRODUCT...
    445-7009-GEN
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  • Complete Freund's Adjuvant, 10 mg/ml

    Complete Freund's Adjuvant, 10 mg/ml

    445

    NULL226.00
    Complete Freund's Adjuvant, 10 mg/ml - Cat Number: 7027 From . Research Field: In vivo Research Clonality: N/A Cross-Reactivity: Host Origin: N/A Applications: N/A Isotype: N/A Detection Range: N/A Sample Type: N/A Concentration: N/A Immunogen: PRODUCT...
    445-7027-GEN
    NULL226.00
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  • Complete Freund's Adjuvant, 1 mg/ml

    Complete Freund's Adjuvant, 1 mg/ml

    445

    NULL127.00
    Complete Freund's Adjuvant, 1 mg/ml - Cat Number: 7008 From . Research Field: In vivo Research Clonality: N/A Cross-Reactivity: Host Origin: N/A Applications: N/A Isotype: N/A Detection Range: N/A Sample Type: N/A Concentration: N/A Immunogen: PRODUCT...
    445-7008-GEN
    NULL127.00
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