1-NM-PP1 | B2346

1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. Inhibits multiple tyrosine kinase targets, such as v-Src (IC50 = 1 μM), c-Fyn (IC50 = 0.6 μM), c-Abl (IC50 = 0.6 μM), CDK2 (IC50: 18 μM), and CaMK II (IC50 = 22 μM). Addiitonally, 1-NM-PP1 is reported to be a potent and specific inhibitor of TrkB-F616A and TrkA-F592A signaling (IC50 values ~ 3 nM).

1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. Inhibits multiple tyrosine kinase targets, such as v-Src (IC50 = 1 μM), c-Fyn (IC50 = 0.6 μM), c-Abl (IC50 = 0.6 μM), CDK2 (IC50: 18 μM), and CaMK II (IC50 = 22 μM). Addiitonally, 1-NM-PP1 is reported to be a potent and specific inhibitor of TrkB-F616A and TrkA-F592A signaling (IC50 values ~ 3 nM).

B2346 | 1-NM-PP1 DataSheet

Alternate Name/Synonyms: 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine,PP1 analog II

Appearance: White solid

Formulation:

CAS Number: 221244-14-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₀H₂₁N₅

Molecular Weight: 331.41

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >25 mg/ml (DMSO)

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases

MDL Number:

PubChem CID: 5154691

SMILES: CC(C)(C)N1C2=C(C(=N1)CC3=CC=CC4=CC=CC=C43)C(=NC=N2)N

InChi: InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23)

InChi Key: GDQXJQSQYMMKRA-UHFFFAOYSA-N