17-DMAG hydrochloride | 1776

A water-soluble analog of 17-AAG (Cat. No. 1774-1,5) that displays better stability and low in vivo toxicity similar to 17-AAG, but undergoes limited metabolism compared to 17-AAG. Binds specifically to heat shock protein90 (Hsp90) in a manner similar to geldanamycin.

17-DMAG is a water-soluble analog of 17-AAG (Cat. No. 1774-1,5) that displays better stability and low in vivo toxicity similar to 17-AAG, but undergoes limited metabolism compared to 17-AAG. Binds specifically to heat shock protein90 (Hsp90) in a manner similar to geldanamycin.

1776 | 17-DMAG hydrochloride DataSheet

Alternate Name/Synonyms: 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride; Alvespimycin

Appearance: Purple solid

Formulation: N/A

CAS Number: 467214-21-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₄₈N₄O₈•HCl

Molecular Weight: 653.21

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO or H₂O ( 2 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Hsp90 inhibitor

MDL Number: N/A

PubChem CID: 9852573

SMILES: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl

InChi: InChI=1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1

InChi Key: DFSYBWLNYPEFJK-IHLRWNDRSA-N