2-Hexyl-4-Pentynoic Acid | B2834

2-Hexyl-4-Pentynoic Acid is an inhibitor of histone deacetylases (HDACs). It is a derivative of Valproic acid. It inhibits HDAC activity with an IC₅₀ of 13 μM, compared to an IC₅₀ of 398 μM for Valproic acid. It induces histone hyperacetylation at a concentration of 5 μM in cerebellar granule cells and increases HSP70-1a and HSP70-1b mRNA levels at 50 μM. It is neuroprotective against glutamate-induced excitotoxicity.

2-Hexyl-4-Pentynoic Acid is an inhibitor of histone deacetylases (HDACs). It is a derivative of Valproic acid. It inhibits HDAC activity with an IC₅₀ of 13 μM, compared to an IC₅₀ of 398 μM for Valproic acid. It induces histone hyperacetylation at a concentration of 5 μM in cerebellar granule cells and increases HSP70-1a and HSP70-1b mRNA levels at 50 μM. It is neuroprotective against glutamate-induced excitotoxicity.

B2834 | 2-Hexyl-4-Pentynoic Acid DataSheet

Alternate Name/Synonyms: 2-prop-2-ynyloctanoic acid; 2-Propargyloctanoic Acid

Appearance: Oil

Formulation:

CAS Number: 96017-59-3

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₁₁H₁₈O₂

Molecular Weight: 182.26

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~20 mg/ml in in DMSO, ~16 mg/ml in DMF in 0, ~33 mg/ml in in Ethanol, ~2mg/ml in PBS, pH 7.2 in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of HDACs

MDL Number: MFCD00946863

PubChem CID: 175664

SMILES: CCCCCCC(CC#C)C(=O)O

InChi: InChI=1S/C11H18O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h2,10H,3,5-9H2,1H3,(H,12,13)

InChi Key: DUQSBRQHALCSLC-UHFFFAOYSA-N