5-Aza-2'-deoxycytidine | 1754

An epigenetic modifier. Decitabine is an analogue of the nucleoside 2’-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. DNA hypomethylation is achieved at concentrations below those required to significantly inhibit DNA synthesis, which may promote restoration of function to genes associated with control of cellular differentiation and proliferation.

5-Aza-2'-deoxycytidine is an epigenetic modifier. Decitabine is an analogue of the nucleoside 2’-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis.

1754 | 5-Aza-2'-deoxycytidine DataSheet

Alternate Name/Synonyms: 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-triazin-2(1H)-one; Decitabine

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 2353-33-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₈H₁₂N₄O₄

Molecular Weight: 228.08

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (25 mg/ml), 50% acetic acid (25 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An epigenetic modifier

MDL Number: MFCD00043011

PubChem CID: 451668

SMILES: C1C(C(OC1N2C=NC(=NC2=O)N)CO)O

InChi: InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1

InChi Key: XAUDJQYHKZQPEU-KVQBGUIXSA-N