5-Azacytidine | 1854

A potent growth inhibitor and cytotoxic agent; a potent DNA methyltransferase inhibitor. Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes. Also recently shown to increase reprogramming efficiency of stem cells 10-fold.

5-Azacytidine is a potent growth inhibitor and cytotoxic agent; a potent DNA methyltransferase inhibitor. Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes.

1854 | 5-Azacytidine DataSheet

Alternate Name/Synonyms: 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, Ladakamycin

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 320-67-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₈H₁₂N₄O₅

Molecular Weight: 244.2

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: AcOH: H₂O (1:1) (5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A DNA methyltransferase inhibitor

MDL Number: MFCD00006539

PubChem CID: 1805

SMILES: C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N

InChi: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)

InChi Key: NMUSYJAQQFHJEW-UHFFFAOYSA-N