8-Hydroxy-2-deoxyguanosine is produced by oxidative damage of DNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a critical biomarker of oxidative...
A DNA methyltransferase (DNMT) inhibitor. Acts as a tumor-selective prodrug of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP (FdUMP).2'-deoxy-5-fluorocytidine is a DNA methyltransferase...
6-Thio-dG induces telomere dysfunction in telomerase-positive human cancer cells and hTERT-expressing human fubroblasts, but not in telomerase-negative cells. Treatment with 6-thio-dG results in...