A-196 | B3252

A-196 is a potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively). Displays 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits the di- and tri-methylation of H4K20me in multiple cell lines (IC50 < 1 μM).

A-196 is a potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively). Displays 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits the di- and tri-methylation of H4K20me in multiple cell lines (IC50 < 1 μM).

B3252 | A-196 DataSheet

Alternate Name/Synonyms: Cyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine

Appearance: Crystalline solid

Formulation:

CAS Number: 1982372-88-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₆Cl₂N₄

Molecular Weight: 359.25

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective SUV420H1/H2 inhibitor

MDL Number: MFCD29924807

PubChem CID: 117072548

SMILES: C1CCC(C1)NC2=NN=C(C3=CC(=C(C=C32)Cl)Cl)C4=CC=NC=C4

InChi: InChI=1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)

InChi Key: ABGOSOMRWSYAOB-UHFFFAOYSA-N