a Synuclein (Ab 133) Antibody | 79-603

a Synuclein (Ab 133) Antibody | 79-603 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: a-Synuclein (Ab-133) antibody was raised against a peptide sequence around aa. 131~135 (E-G-Y-Q-D) derived from Human α-Synuclein.

Research Area: Neuroscience

Tested Application: WB, IF

Application: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Specificiy: This antibody detects endogenous level of total Synuclein protein.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 18 kDa

Validation: N/A

Isoform: N/A

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+) , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Concentration: 1 mg/mL

Storage Condition: Store antibody at -20˚C for up to one year.

Alternate Name: PD1, NACP, PARK1, PARK4, SYN, SYUA, alpha-synuclein

User Note: N/A

BACKGROUND: May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies) . Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.