Ac-DEVD-CHO | B1951

Ac-DEVD-CHO is a potent and reversible inhibitor of the Group II caspases, caspase-3 and caspase-7 (Ki's = 0.23 and 1.6 nM, respectively). The DEVD sequence is based on PARP cleavage site Asp-216 for caspase-3.

Ac-DEVD-CHO is a potent and reversible inhibitor of the Group II caspases, caspase-3 and caspase-7 (Ki's = 0.23 and 1.6 nM, respectively). The DEVD sequence is based on PARP cleavage site Asp-216 for caspase-3.

B1951 | Ac-DEVD-CHO DataSheet

Alternate Name/Synonyms: Ac-Asp-Glu-Val-Asp-CHO; caspase-3 inhibitor

Appearance: Lyophilized solid

Formulation: N/A

CAS Number: 169332-60-9

Structure Available?: Yes

Peptide sequence: Ac-Asp-Glu-Val-Asp-CHO

Salt Form: No

Molecular Formula: C₂₀H₃₀N₄O₁₁

Molecular Weight: 502.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A reversible caspase-3 inhibitor

MDL Number: MFCD00671412

PubChem CID: 644345

SMILES: CC(C)C(C(=O)NC(CC(=O)O)C=O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C

InChi: InChI=1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4

InChi Key: UMBVAPCONCILTL-MRHIQRDNSA-N