ACLY Antibody [6E7D7] | 23-966

ACLY Antibody [6E7D7] | 23-966 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Monkey

Homology: N/A

Immunogen: Recombinant protein of human ACLY

Research Area: Cancer, Signal Transduction

Tested Application: WB, ICC, Flow

Application: WB: 1:500 - 1:2000
ICC: 1:50 - 1:200
Flow: 1:20 - 1:50

Specificiy: N/A

Positive Control 1: HeLa

Positive Control 2: K-562

Positive Control 3: COS-7

Positive Control 4: HepG2

Positive Control 5: Raji

Positive Control 6: NIH/3T3

Molecular Weight: Observed: 121kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Monoclonal

Clone: [6E7D7]

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: ACL, ATPCL, CLATP, ATP-citrate synthase, ATP-citrate (pro-S-) -lyase, citrate cleavage enzyme

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440, 000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.