ACOT8 Antibody (C-term) [APG01502G]

ACOT8 Antibody (C-term) [APG01502G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M, Rat

Specificity: This ACOT8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 275-310 amino acids from the C-terminal region of human ACOT8.

Cellular Localisation: Peroxisome matrix. Note=Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded

Molecular Weight: 35914

Clone: Polyclonal

Gene Name: ACOT8

Gene ID: 10005

Function: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:9299485, PubMed:9153233, PubMed:15194431) . Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity) . Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9299485, PubMed:9153233) . Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity) . Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity) . It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431) .

Summary: Tissue Location: Detected in a T-cell line (at protein level) . Ubiquitous (PubMed:9153233, PubMed:9299485)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Acyl-coenzyme A thioesterase 8, Acyl-CoA thioesterase 8, Choloyl-coenzyme A thioesterase, HIV-Nef-associated acyl-CoA thioesterase, PTE-2, Peroxisomal acyl-coenzyme A thioester hydrolase 1, PTE-1, Peroxisomal long-chain acyl-CoA thioesterase 1, Thioesterase II, hACTE-III, hACTEIII, hTE, ACOT8, ACTEIII, PTE1, PTE2