Activin Receptor IIB Antibody | 36-351

Activin Receptor IIB Antibody | 36-351 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: Recombinant extracellular domain (ecd) of mouse activin receptor IIB.

Research Area: Cancer, Immunology, Innate Immunity, Neuroscience

Tested Application: E, WB

Application: ELISA: (1:400) . Western Blot: (1:5000) . Optimal conditions must be determined individually for each application.

Specificiy: Recognizes the extracellular domain of human and mouse ACTR-IIB. Does not cross-react with related human proteins ActR-IIecd, BMPR-IIecd, BMPR-IAecd, BMPR-IBecd or ActR-Iecd.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Antigen affinity purified.

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Liquid. In PBS with 1 mg/ml BSA and 0.02% sodium azide.

Concentration: 500 ug/ml

Storage Condition: Stable for at least 1 year after receipt when stored at -20˚C.

Alternate Name: ACVR2B; ACTR-IIB; Activin receptor type-2B

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Activin Receptor IIB (ACTR-IIB) is a transmembrane receptor that forms an activin receptor complex with activin type-1 receptors (ACVR1, ACVR1B or ACVR1c) . ACTR-IIB transduces the activin signal from the cell surface to the cytoplasm and regulates therefore many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.