ACTL6A Antibody | 19-632

ACTL6A Antibody | 19-632 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ACTL6A (NP_004292.1) .

Research Area: Cell Cycle, Signal Transduction

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: HT-29

Positive Control 2: K-562

Positive Control 3: MCF7

Positive Control 4: BT-474

Positive Control 5: Mouse spleen

Positive Control 6: Mouse testis

Molecular Weight: Observed: 48kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: ACTL6, ARPN-BETA, Arp4, BAF53A, INO80K, actin-like protein 6A, 53 kDa BRG1-associated factor A, BAF complex 53 kDa subunit, BAF53, BRG1-associated factor 53A, INO80 complex subunit K, actin-related protein 4, actin-related protein Baf53a, arpNbeta, hArpN beta

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a family member of actin-related proteins (ARPs) , which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.