ADAMTS4 Antibody (C-term) [APR32442G]

ADAMTS4 Antibody (C-term) [APR32442G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 705-736 amino acids from the C-terminal region of human ADAMTS4.

Cellular Localisation: Secreted, extracellular space, extracellular matrix

Molecular Weight: 90197

Clone: Polyclonal

Gene Name: ADAMTS4

Gene ID: 9507

Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Summary: Tissue Location: Expressed in brain, lung and heart (PubMed:23897278) . Expressed at very low level in placenta and skeletal muscles (PubMed:23897278) . Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688