ADCY8 Antibody (Center) [APG01558G]

ADCY8 Antibody (Center) [APG01558G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ADCY8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 946-972 amino acids from the Central region of human ADCY8.

Cellular Localisation: Cell membrane {ECO:0000250|UniProtKB:P97490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97490}. Basolateral cell membrane {ECO:0000250|UniProtKB:P97490}. Apical cell membrane {ECO:0000250|UniProtKB:P97490}. Cell junction, synapse {ECO:0000250|UniProtKB:P97490}. Cell projection, dendrite {ECO:0000250|UniProtKB:P97490}. Cell projection, axon {ECO:0000250|UniProtKB:P97490}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:P97490}. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:P97490}. Membrane raft {ECO:0000250|UniProtKB:P40146}. Membrane, coated pit {ECO:0000250|UniProtKB:P40146}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P40146}. Membrane, caveola {ECO:0000250|UniProtKB:P40146}. Note=Localized to dendritic arbors (By similarity) . Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also localized outside of membrane rafts. Membrane raft localization and integrity is indispensable for CCE-stimulated adenylate cyclase activity (By similarity) . {ECO:0000250|UniProtKB:P40146, ECO:0000250|UniProtKB:P97490}

Molecular Weight: 140122

Clone: Polyclonal

Gene Name: ADCY8

Gene ID: 114

Function: Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon- like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.

Summary: Tissue Location: Detected in brain cortex (PubMed:1715695) . Expressed in islet (PubMed:25403481) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, FC, WB

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Adenylate cyclase type 8, ATP pyrophosphate-lyase 8, Adenylate cyclase type VIII, Adenylyl cyclase 8, AC8, Ca (2+) /calmodulin-activated adenylyl cyclase, ADCY8