Adducin α (phospho-T445) polyclonal Antibody | BS4258

Adducin α (phospho-T445) polyclonal Antibody | BS4258 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: Adducins are a family of cytoskeleton proteins encoded by three genes (α, β, γ) . Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin α is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin α and Adducin γ is ubiquitous in contrast to the restricted expression of Adducin β. Adducin β is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Adducin α (T445) polyclonal Antibody detects endogenous levels of Adducin α protein only when phosphorylated at Thr445.

Molecular Weight: ~ 81 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Alpha-adducin; Erythrocyte adducin subunit alpha; ADD1; ADDA; α-Adducin; Adducin1; Adducin-1; α Adducin;

Immunogen: Synthetic phosphopeptide derived from human Adducin α around the phosphorylation site of Threonine 445.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: