AEM1 | B2611

AEM1 is an inhibitor of Nrf2-induced gene transcription at the antioxidant response element in cells at 1 to 10 µM. It sensitizes lung carcinoma A549 cells to chemotherapeutic agents and inhibits the growth of A549 cells in vitro and in vivo in animals.

AEM1 is an inhibitor of Nrf2-induced gene transcription at the antioxidant response element in cells at 1 to 10 µM. It sensitizes lung carcinoma A549 cells to chemotherapeutic agents and inhibits the growth of A549 cells in vitro and in vivo in animals.

B2611 | AEM1 DataSheet

Alternate Name/Synonyms: N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine

Appearance: Crystalline solid

Formulation:

CAS Number: 1030123-90-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₄FN₃O₂S

Molecular Weight: 379.41

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of Nrf2-induced gene transcription

MDL Number:

PubChem CID: 9196193

SMILES: C1OC2=C(O1)C=C(C=C2)CNC3=C4C(=CSC4=NC=N3)C5=CC=C(C=C5)F

InChi: InChI=1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24)

InChi Key: QGYLTGSHWIGJJD-UHFFFAOYSA-N