AIMP1 Antibody | 7513

AIMP1 Antibody | 7513 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Chicken: (73%)

Immunogen: AIMP1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human AIMP1.
The immunogen is located within amino acids 240 - 290 of AIMP1.

Research Area: Immunology

Tested Application: E, WB, IHC-P

Application: AIMP1 antibody can be used for detection of AIMP1 by Western blot at 1 μg/ml.
Antibody validated: Western Blot in human, mouse, and rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Specificiy: AIMP1 antibody is human, mouse and rat reactive. At least two isoforms of AIMP1 are known to exist; this antibody will recognize both isoforms. AIMP1 antibody is predicted to not cross-react with AIMP2.

Positive Control 1: Cat. No. 1463 - Rat Brain Tissue Lysate

Positive Control 2: Cat. No. 1303 - Human Brain Tissue Lysate

Positive Control 3: Cat. No. 1403 - Mouse Brain Tissue Lysate

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 46 kDa
Observed: 36 kDa

Validation: N/A

Isoform: N/A

Purification: AIMP1 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: AIMP1 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: AIMP1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: AIMP1 Antibody: p43, HLD3, EMAP2, SCYE1, EMAPII, Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, EMAP-2

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: AIMP1 (Endothelial monocyte-activating polypeptide II, EMAP2) is a proinflammatory cytokine for monocytes and granulocytes (1) . It is specifically induced by apoptosis and is involved in the control of angiogenesis, inflammation, and wound healing (1, 2) . AIMP1 was identified as one of three auxiliary factors of the mammalian aminoacyl tRNA synthetase (ARS) complex. It binds and facilitates the catalytic reaction of arginyl-tRNA synthetase (2, 3) . Recent studies show that CD23 plays an essential role in the AIMP1-induced immune response and might be a target in the treatment of inflammatory diseases (4) .