AIMP2 Antibody | 7515

AIMP2 Antibody | 7515 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2.
The immunogen is located within amino acids 150 - 200 of AIMP2.

Research Area: Apoptosis

Tested Application: E, WB, IHC-P, IF

Application: AIMP2 antibody can be used for detection of AIMP2 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Specificiy: AIMP2 antibody is human specific. AIMP2 antibody is predicted to not cross-react with AIMP1.

Positive Control 1: Cat. No. 1201 - HeLa Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 35 kDa
Observed: 36 kDa

Validation: N/A

Isoform: N/A

Purification: AIMP2 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: AIMP2 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: AIMP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: AIMP2 Antibody: P38, JTV1, JTV-1, PRO0992, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1) . It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson’s disease; accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2) . AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3) . Finally, AIMP2 has been suggested to function as a tumor suppressor (4) .