ALKBH3 polyclonal Antibody | BS7871

ALKBH3 polyclonal Antibody | BS7871 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:2000

Background: ALKBH3 (alkB, alkylation repair homolog 3), also known as ABH3, PCA1 (prostate cancer antigen 1), DEPC1 or DEPC-1, is a 286 amino acid member of the AlkB family of proteins and functions as a dioxygenase with a preference for RNA and single stranded DNA substrates. ALKBH3 is one of many homologs of the Escherichia coli protein, AlkB. ALKBH3 is expressed in a wide variety of tissues and localizes to the cytoplasm and the nucleus. It associates with iron and 2-oxoglutarate, coupling the oxidation of substrates to the conversion of 2-oxoglutarate into succinate and CO2. Via oxidative demethylation, ALKBH3 repairs 1-methyladenine and 3-methylcytosine lesions in alkylated DNA and RNA. Its activity is stimulated by ascorbate. Two isoforms exist for ALKBH3 due to alternative splicing of the gene.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ALKBH3 polyclonal Antibody detects endogenous levels of ALKBH3 protein.

Molecular Weight: ~ 33 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ABH3; AlkB homolog 3; alkB, alkylation repair homolog 3 (E. coli) ; ALKB3_HUMAN; ALKBH3; Alkylated DNA repair protein alkB homolog 3; alkylation repair homolog 3; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; DEPC 1; DEPC-1; DEPC1; EC 1.14.11.; FLJ43614; mABH3; MGC118790; MGC118792; MGC118793; MGC134125; PCA1; Prostate cancer antigen 1; prostate cancer antigen-1; RP23-375N21.4;

Immunogen: Recombinant full length Human ALKBH3.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: