ALKBH4 polyclonal Antibody | BS70932

ALKBH4 polyclonal Antibody | BS70932 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: ALKBH4 (alkB, alkylation repair homolog 4), also known as ABH4, is a 302 amino acid protein belonging to the alkB family. ALKBH4 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. ALKBH4 exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ALKBH4 polyclonal Antibody detects endogenous levels of ALKBH4 protein.

Molecular Weight: Refer to figures

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ABH4;

Immunogen: Recombinant protein of human ALKBH4.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: