Alpha 1 Antichymotrypsin, Human Plasma | 7293

Alpha 1 antichymotrypsin is an acute-phase plasma protein found at 45 mg per 100 ml. ACT functions as a specific inhibitor of chymotrypsin-like serine proteases. Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Clinically, it is elevated in inflammatory conditions, some malignancies, Crohn's disease, ulcerative colitis, and burn injuries. The PSA-ACT complex level is considered a biomarker for prostate cancer. Defects in this gene may be a cause of chronic obstructive pulmonary disease.

7293 | Alpha 1 Antichymotrypsin Human Plasma DataSheet

Biomolecule/Target: SERPINA3

Synonyms: Cell growth-inhibiting gene 24/25 protein, Serpin A3, SERPINA3, AACT, GIG24, GIG25

Alternates names: Cell growth-inhibiting gene 24/25 protein, Serpin A3, SERPINA3, AACT, GIG24, GIG25

Taglines: An acute-phase plasma protein

NCBI Gene ID #: 12

NCBI Gene Symbol: SERPINA3

Gene Source: Human

Accession #: P01011

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Shows 75-100% inhibition when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.

Results: Shows 75-100% inhibition when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 64 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 20 mM Tris-HCl, pH 7.4, with 150 mM NaCl.

Reconstitution Instructions: In water or aqueous buffer

Amino acid sequence: N/A