AM-095 | 9581

AM-095 is a potent LPA1 receptor antagonist with IC₅₀ values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. In functional assays, AM-095 inhibitsLPA-driven chemotaxis of CHO cells overexpressing mouse LPA₁ (IC₅₀ = 778 nM) and human A2058 melanoma cells (IC₅₀ = 233 nM).

AM-095 is a potent LPA1 receptor antagonist with IC₅₀ values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. In functional assays, AM-095 inhibitsLPA-driven chemotaxis of CHO cells overexpressing mouse LPA₁ (IC₅₀ = 778 nM) and human A2058 melanoma cells (IC₅₀ = 233 nM).

9581 | AM-095 DataSheet

Alternate Name/Synonyms: 2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1228690-36-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₄N₂O₅

Molecular Weight: 456.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent LPA1 receptor antagonist

MDL Number: N/A

PubChem CID: 46213949

SMILES: CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O

InChi: InChI=1S/C27H24N2O5/c1-17-25(28-27(32)33-18(2)20-6-4-3-5-7-20)26(34-29-17)23-14-12-22(13-15-23)21-10-8-19(9-11-21)16-24(30)31/h3-15,18H,16H2,1-2H3,(H,28,32)(H,30,31)/t18-/m1/s1

InChi Key: LNDDRUPAICPXIN-GOSISDBHSA-N