AMACR/P504S monoclonal Antibody | MB9051

AMACR/P504S monoclonal Antibody | MB9051 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Application: WB IHC FC

Application Range: WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100

Background: AMACR, is an enzyme that responsible for converting (2R) -methylacyl-CoA esters to their (2S) -methylacyl-CoA epimers and known substrates, including coenzyme A esters of pristanic acid (mostly derived from phytanic acid, a 3-methyl branched-chain fatty acid that is abundant in the diet) and bile acids derived from cholesterol. Both decreased and increased levels of the enzyme in humans are linked with diseases. Reduction of the protein level or activity results in the accumulation of (2R) -methyl fatty acids such as bile acids which causes neurological symptoms. Increased levels of AMACR protein concentration and activity are associated with prostate cancer, and the enzyme is used widely as a biomarker (known in cancer literature as P504S) in biopsy tissues. Increased levels of AMACR are also associated with some breast, colon, and other cancers, but it is unclear exactly what the role of AMACR is in these cancers. This AMACR Antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalinfixed, paraffin-embedded tissue sections using IHC test methods.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: AMACR/P504S monoclonal Antibody detects endogenous levels of AMACR/P504S protein.

Molecular Weight: 42 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: AMACR, 2 arylpropionyl CoA epimerase, 2 methylacyl CoA racemase, 2-methylacyl-CoA racemase, Alpha methylacyl CoA racemase, Alpha methylacyl Coenzyme A racemase, Alpha methylacyl-CoA racemase deficiency, included, Alpha-methylacyl-CoA racemase, Amacr, AMACR deficiency, included, AMACR_HUMAN Antibody CBAS4, Da1-8, EC 5.1.99.4, Macr1, Methylacyl CoA racemase alpha, RACE, RM,

Immunogen: Recombinant full length protein of human AMACR.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProG affinity purified.

Pathway: