Amastatin hydrochloride | B3085

Amastatin is an inhibitor of aminopeptidase A and leucine aminopeptidase (IC₅₀ values of 0.54 μg/ml and 0.5 μg/ml). It does not show any significant inhibition of aminopeptidase B, trypsin, chymotrypsin, elastase, papain, pepsin or thermolysin. It is a competitive inhibitor of aminopeptidase N. Inhibitors of aminopeptidase N can be beneficial in inhibiting COVID-19.

Amastatin is an inhibitor of aminopeptidase A and leucine aminopeptidase (IC₅₀ values of 0.54 μg/ml and 0.5 μg/ml). It does not show any significant inhibition of aminopeptidase B, trypsin, chymotrypsin, elastase, papain, pepsin or thermolysin. It is a competitive inhibitor of aminopeptidase N. Inhibitors of aminopeptidase N can be beneficial in inhibiting COVID-19.

B3085 | Amastatin hydrochloride DataSheet

Alternate Name/Synonyms: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]butanedioic acid, hydrochloride; N-[(2S,3R)-3-amino-2-hydroxy-5-methyl-1-oxohexyl]-L-valyl-L-valyl-L-aspartic acid, monohydrochloride

Appearance: White powder

Formulation:

CAS Number: 100938-10-1

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₂₁H₃₉ClN₄O₈

Molecular Weight: 511

Cell-Permeable?: True

Purity: ≥ 95%

Solubilities: ~1 mg/ml in ethanol, ~10 mg/ml in DMF, ~5 mg/ml in PBS, pH 7.2, ~2 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of aminopeptidase A and leucine aminopeptidase

MDL Number: MFCD00150636

PubChem CID: 180936

SMILES: CC(C)CC(C(C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(=O)O)C(=O)O)O)N.Cl

InChi: InChI=1S/C21H38N4O8.ClH/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27;/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33);1H/t12-,13+,15+,16+,17+;/m1./s1

InChi Key: GBDUPCKQTDKNLS-PORDUOSCSA-N