AMG-517 | B3019

AMG-517 is an antagonist of transient receptor potential vanilloid 1 (TRPV1) with an IC₅₀ of 0.9 nM. It inhibits post-burn mechanical and thermal allodynia in a rat model of burn injury when administered intrathecally at a dose of 165 µg. It (150 and 300 µg/kg) decreases calcitonin gene-related peptide (CGRP) release from spinal dorsal horn and promotes peripheral nerve regeneration in a rat model of sciatic nerve transection injury.

AMG-517 is an antagonist of transient receptor potential vanilloid 1 (TRPV1) with an IC₅₀ of 0.9 nM. It inhibits post-burn mechanical and thermal allodynia in a rat model of burn injury when administered intrathecally at a dose of 165 µg. It (150 and 300 µg/kg) decreases calcitonin gene-related peptide (CGRP) release from spinal dorsal horn and promotes peripheral nerve regeneration in a rat model of sciatic nerve transection injury.

B3019 | AMG-517 DataSheet

Alternate Name/Synonyms: N-[4-[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide; N-(4-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)oxy)benzo[d]thiazol-2-yl)acetamide

Appearance: Off White solid

Formulation:

CAS Number: 659730-32-2

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₀H₁₃F₃N₄O₂S

Molecular Weight: 430.4

Cell-Permeable?: TRUE

Purity: >98%

Solubilities: ~14 mg/ml in DMSO, ~3 mg/ml in Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antagonist of transient receptor potential vanilloid 1 (TRPV1)

MDL Number: MFCD14584859

PubChem CID: 16007367

SMILES: CC(=O)NC1=NC2=C(C=CC=C2S1)OC3=NC=NC(=C3)C4=CC=C(C=C4)C(F)(F)F

InChi: InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)

InChi Key: YUTIXVXZQIQWGY-UHFFFAOYSA-N