AMMC iodide | 2873

AMMC iodide is a useful substrate for the human cytochrome P450 CYP2D6 isozyme. It is demethylated to the fluorescent product 3-[2-(N,N-diethyl-N-methyl ammonium)ethyl]-7-hydroxy-4-methylcoumarin (AMHC). After the AMMC is hydrolyzed, the pH is increased by addition of base for optimal fluorescence detection. AMMC has been used with human liver microsomes to determine CYP2D6 activity and inhibition.

AMMC iodide is a useful substrate for the human cytochrome P450 CYP2D6 isozyme. It is demethylated to the fluorescent product 3-[2-(N,N-diethyl-N-methyl ammonium)ethyl]-7-hydroxy-4-methylcoumarin (AMHC). After the AMMC is hydrolyzed, the pH is increased by addition of base for optimal fluorescence detection. AMMC has been used with human liver microsomes to determine CYP2D6 activity and inhibition.

2873 | AMMC iodide DataSheet

Alternate Name/Synonyms: 3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin iodide

Appearance: Off-white solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₆INO₃

Molecular Weight: 431.31

Cell-Permeable?: No

Purity: ≥98% by NMR

Solubilities: Acetonitrile

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A useful substrate for human cytochrome P450 CYP2D6

MDL Number: MFCD13184322

PubChem CID: 15487105

SMILES: CC[N+](C)(CC)CCC1=C(C2=C(C=C(C=C2)OC)OC1=O)C.[I-]

InChi: InChI=1S/C18H26NO3.HI/c1-6-19(4,7-2)11-10-16-13(3)15-9-8-14(21-5)12-17(15)22-18(16)20;/h8-9,12H,6-7,10-11H2,1-5H3;1H/q+1;/p-1

InChi Key: OAQIUABCTPFMOC-UHFFFAOYSA-M