AMOTL2 Antibody (Center) [APR32609G]

AMOTL2 Antibody (Center) [APR32609G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This AMOTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-152 amino acids from the Central region of human AMOTL2.

Cellular Localisation: Recycling endosome.

Molecular Weight: 85764

Clone: Polyclonal

Gene Name: AMOTL2

Gene ID: 51421

Function: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Angiomotin-like protein 2, Leman coiled-coil protein, LCCP, AMOTL2, KIAA0989